Identification of EFHD1 as a novel Ca2+ sensor for mitoflash activation

Tingting Hou,Chongshu Jian,Jiejia Xu,August Yue Huang,Jianzhong Xi,Keping Hu, Liping Wei,Heping Cheng,Xianhua Wang

Cell Calcium（2016）

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摘要

•Identified four Ca2+-linked mitoflash activators (MICU1, SLC25A23, SLC25A25, EFHD1) and one inhibitor (LETM1).•Identified EFHD1 as a novel mitochondrial Ca2+ sensor for Ca2+-dependent mitoflash activation.•EF-hand domains of EFHD1 are required for its mitoflash-regulatory effects.

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关键词

mPTP,fMPT,ROS,cpYFP,RNAi

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