Solithromycin Pharmacokinetics In Plasma And Dried Blood Spots And Safety In Adolescents

We assessed the pharmacokinetics and safety of solithromycin, a fluoroketolide antibiotic, in a phase 1, open-label, multicenter study of 13 adolescents with suspected or confirmed bacterial infections. On days 3 to 5, the mean (standard deviation) maximum plasma concentration and area under the concentration versus time curve from 0 to 24 h were 0.74 mu g/ml (0.61 mu g/ml) and 9.28 mu g.h/ml (6.30 mu g.h/ml), respectively. The exposure and safety in this small cohort of adolescents were comparable to those for adults.