Metastatic cholangiocellular carcinoma in Kankrej bullock

Sixteen years old castrated Kankrej male was found dead after short clinical illness. On necropsy, multiple yellow to yellowish white, umbilicated, well demarcated, firm nodules of 3 to 20 cm in size were found on liver, lung, adrenals, lymph nodes and thoracic wall. Histologically, neoplasm was composed of round to polygonal cells arranged in irregular mass, poorly formed ducts, supported by a moderate to dense collagenous fibrovascular stroma. Neoplasm was diagnosed as poorly differentiated cholangiocellular carcinoma with desmoplasia. Diagnosis was confirmed by positive cytokeratin 7/17 immunostaining.