Impact of 5 Fluorouracil Chemotherapy on Gut Inflammation, Functional Parameters, and Gut Microbiota.

A T Sougiannis,B N VanderVeen,R T Enos,K T Velazquez, J E Bader, M Carson,I Chatzistamou,M Walla,M M Pena,J L Kubinak,M Nagarkatti,J A Carson,E A Murphy

Brain, Behavior, and Immunity（2019）

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摘要

•5FU increases mortality and symptom severity despite anti-tumor effects.•Colon inflammation is elevated with 5FU and this is further exacerbated with cancer.•5FU and cancer lead to dissimilarity and alterations in gut bacterial taxonomy.•5FU reduces grip strength and run-to-fatigue performance in cancer mice.•A 5FU altered microbiome influences the immune milieu and functional parameters.

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5-Fluorouracil,Chemotherapy,Toxicity,Colorectal cancer,Inflammation,Microbiota,Fecal transplant

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