Using Mouse Models to Unlock the Secrets of Non-Synonymous RNA Editing

•Functional consequences of re-coding RNA editing is commonly studied in mouse models.•Existing mouse models include ADAR null and all-or-none editing of individual RNAs.•In vivo studies should consider variables known to influence editing frequency.•Sanger and next generation sequencing may be used to quantify RNA editing.•Mass spectrometry may be useful to quantify RNA editing-dependent protein levels.