Testosterone therapy and venous thromboembolism: A systematic review and meta-analysis

•The Food and Drug Administration warns against VTE in testosterone users.•6 RCTs and 5 observational studies examining testosterone and VTE are reviewed.•No significant association was found between testosterone and VTE.•Limited data from RCTs and heterogeneity in observational studies limit conclusions.•We conclude our review with 8 summarizing clinical management considerations.