1813PPrevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC)

B C M Hermans,J.L. Derks, E Thunissen,R. J. van Suylen,M. A. den Bakker,Harry J.M. Groen,Egbert F. Smit,R. Damhuis,E. van den Broek, P PALGA-group, C M Stallinga, G M Roemen,E J Speel,A. Dingemans

Annals of Oncology（2019）

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摘要

PD-L1 expression was positive in 16% of stage IV LCNEC tumors. This was independent of molecular subtype but associated with CD8 expression. In LCNEC patients with PD-L1 and/or CD8 expression superior OS was observed.

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关键词

CD8,Large cell neuroendocrine carcinoma,Lung cancer,PD-L1,Prognosis

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