Silicon photomultipliers applied to the fluorescence detection of biomarkers
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment(2019)
摘要
The silicon photomultiplier (SiPM) has advantages that allow it to detect low levels of light intensity in medical, chemical and biological applications; it can also build integrated, portable microfluidic systems. This paper presents a SIPM application designed for the detection of fluorescence of biomarkers. In order to minimise the volume of the tested sample, the measurements were conducted in a microfluidic system. A data acquisition system for the SiPM has been designed consisting of a dedicated application specific integrated circuit (ASIC) required to amplify and shape signals from the photodetector. The application has been designed with the aim of transforming it into a portable device. The detection method chosen in the research is based on flow cytometry and single molecule detection [1], [2]. Although only a single photodetector was used, the presented applications can be adapted to multi-detector measurements. Initially, the application measured the fluorescence of fluorophores. Afterwards, it was used in the detection of Anti-NPR1 to confirm the effectiveness of the method. The application is not dedicated to a single antigen. It can be applied for the detection of a vast range of biomarkers.
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关键词
Silicon photomultiplier,Biomarkers,Fluorescence detection
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