P1.15-24 Small Cell Lung Cancer: Clinical Characteristics and Survival of a Spanish Cohort of 221 Patients

Lung cancer is the leading cause of death from cancer, of which 15% corresponds with small cell lung cancer (SCLC) subtype, directly related with tobacco. SCLC is the most aggressive subtype with an elevated percentage of metastatic patients at diagnosis and a poor prognosis. A cohort of 221 patients diagnosed of SCLC were retrospectively analyzed in our center between 2008-2016. Patient data was analyzed for baseline demographics and stage at diagnosis. Progression free survival (PFS) and overall survival (OS) analysis were made comparing SCLC stage at diagnosis. The median age at diagnosis was 64 years and 74% were male, of whom 33% were older than 70 years. Only 0.5 % were never smokers and 16% had history of other malignancies, mostly related with tobacco. At diagnosis, 67% were metastatic and 88% symptomatic. Complete baseline characteristics shown at Table 1. PFS was 13.5 versus 6.83 months in located versus metastatic disease (p = 0.000) and median OS was 21.2 versus 8.5 months comparing located and metastatic stage (p = 0.000). Kaplan-Meier curves shown at Image 1. SCLC is mostly diagnosed at metastatic stage, but even in located disease prognosis is poor, so investigation is needed to improve PFS and OS.