Prognostic value of biochemical recurrence following treatment with curative intent for prostate cancer: A systematic review

In patients who underwent radical prostatectomy as primary treatment and who subsequently developed biochemical recurrence (BCR), the main prognostic factor for distant metastases, prostate cancer-specific mortality, and overall mortality is short prostate-specific antigen doubling time (ie, <1yr), and to a lesser extent an increasing pathological Gleason score (GS) and a short interval to biochemical failure (IBF). The main prognostic factors for patients developing BCR following primary radiotherapy are a short IBF (<18mo) and to a lesser extent an increasing biopsy GS.