Xylobiose ameliorates hyperglycemia and dyslipidemia via regulating hepatic lipogenic genes in db/db mice

Diabetes mellitus (DM) is a metabolic disorder in glucose and fat metabolism and has become a major public concern in worldwide. Xylobiose consists of two molecules of xylose and is a major disaccharide in a well-known sweetener, xylo-oligosaccharide. Although it has been reported the hypoglycemic effect of xylo-oligosaccharide, the physiological effect of xylobiose on blood glucose and lipogenesis has not been evaluated. The objective of study was to evaluate the hypoglycemic and hypolipogenic effect of xylobiose in db/db mice. Five- week old male C57BL/KsJ-db/db mice were randomized into 3 groups as follows: (1) a control group of C57BL/6 mice that received AIN93G (Ctrl), (2) a diabetic control group of C57BL/KsJ-db/db mice that received AIN93G (DB), and (3) a group that supplemented with 5% xylobiose as part of the total sucrose content of the diet (XB5). Mice were fed the experimental diets for 6 weeks. Supplementation of xylobiose reduced food and water intake and improved glucose tolerance by reduci...