Phosphorus-nitrogen compounds. Part 44. The syntheses of N,N-spiro bridged cyclotriphosphazene derivatives with (4-fluorobenzyl) pendant arms: Structural and stereogenic properties, DNA interactions, antimicrobial and cytotoxic activities

The nucleophilic Cl replacement reactions of NN-spirobridged octachlorobiscyclotriphosphazene, [N3P3Cl4(NCHMe2)]2, with bidentate ligands at different molar ratios produced monospiro and dispiro biscyclotriphosphazenes with 4-fluorobenzyl pendant arms. The spectral and crystallographic data exhibit that the dispiro biscyclotriphosphazene adopts a trans-trans configuration. The spectroscopic and crystallographic properties, antimicrobial and cytotoxic activities and DNA interactions of the compounds were investigated. The fully substituted mono spiro bridged product has high anticancer and apoptotic activities.