Innate immunosensing of DNA in cellular senescence
Current Opinion in Immunology（2019）
摘要
•Cellular senescence is a key cellular stress response pathway.•Senescent cells produce various bioactive factors referred to collectively as the SASP.•The cGAS-STING pathway regulates the SASP.•cGAS senses cytosolic DNA from micronuclei and CCFs in senescent cells.
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