Design, synthesis and anticancer activity of trifluoromethylphenylamino substituted spiroindoles

•Biologically active 2´-aminoanalogs and 2,2´-diaminoanalogs containing 4-trifluoromethylphenylamino group have been prepared.•The target aminoanalogs were prepared by spirocyclization protocol utilizing thioureas as starting compounds.•Prepared fluorinated aminoanalogs demonstrated notable antiproliferative activity against various cell lines.