Association Of Loss Of Adaptive Pd-L1 Expression With Upregulation Of Pbrm1 Chromatin Regulator In Melanoma.

Daniel Sanghoon Shin,Chen Cheng,Nhat Truong,Mykola Onyshchenko,Gabriel Abril-Rodriguez,Catherine S. Grasso,Begonya Comin-Anduix, Sk Kurdistani,Antoni Ribas

JOURNAL OF CLINICAL ONCOLOGY（2018）

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摘要

12012Background: Primary resistance to anti-PD-1 through genetic mechanisms is rare and may be mediated by loss-of-function (LoF) mutations in JAK1/2 or antigen presentation. 3 out of 48 human mela...

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pbrm1 chromatin regulator,melanoma

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