Tumor Regression Grading After Neoadjuvant Chemotherapy Predicts Long-Term Outcome Of Stage Iiic Epithelial Ovarian Cancer.

5547Background: Prognostic value of tumor regression grading (TRG) after neoadjuvant chemotherapy (NAC) in patients with FIGO stage IIIC epithelial ovarian cancer (EOC) is controversial. Methods: A total of 55 stage IIIC EOC patients who underwent interval debulking surgery (IDS) after NAC at the Department of Gynecology of Liaoning Cancer Hospital and Institute between January 2003 and September 2016 and had full information were involved this retrospective study. All the pathological sections were individually reviewed by two pathologists. TRG was determined by the ratio of viable tumor versus fibrosis, ranging from TRG 0 when no viable tumor, to TRG 5 when fibrosis was absent. TRG 1 was defined as regression more than 75%, TRG 2 was defined as regression more than 50% but less than 75%, TRG 3 was defined as regression more than 25% but less than 50%, and TRG 4 was defined as regression less than 25%. Patients were stratified into TRG 0-1-2 group and TRG 3-4-5 group according to cut-off values calculate...