Hypertension And Beta-Blocker Use As Prognostic And Predictive Factors In Metastatic Colorectal Cancer: A Retrospective Analysis Of Ncic Ctg Co.17

e15025Background: Adrenergic receptor stimulation is involved in the development of hypertension (HTN), and has been implicated in progression and dissemination of metastases in various tumours including colon cancer. Furthermore adrenergic antagonists, such as beta-blockers (BB), demonstrate inhibition of invasion and migration in colon cancer cell lines and have been associated with decreased mortality in colorectal cancer. We examined the association of baseline HTN (bHTN) and use of BB on overall (OS) or progression-free survival (PFS) of pts with pre-treated, chemotherapy refractory, metastatic colorectal cancer (mCRC). We also examined bHTN as a predictor of Cetuximab (CET) efficacy. Methods: Using data from NCIC CO.17 (CET vs. BSC), we coded bHTN and use of anti-HTN medications (Rx), including BB, for 572 pts. Chi-square test was used to assess association between these variables and baseline characteristics. Univariate and multivariate analyses of OS and PFS by bHTN and BB use were performed using...