Development Of Hope-Genomics: An It Platform For Patient-Directed Cancer Genome Sequencing Education And Return Of Results

1532Background: Profiling of somatic/germline tissue has the potential to improve outcomes for patients with cancer. However, the realization of precision medicine is hindered by patients’ limited understanding of genetics and their own tumor/germline results. Innovations to improve patient education and care engagement are urgently needed. Methods: We recruited patients at a comprehensive cancer center to help develop a web-based, patient-directed cancer genomic sequencing education and reporting tool: HOPE-Genomics. We obtained clinical data through patient surveys and chart reviews. We obtained feedback on the tool from patients, family members, and clinicians via focus groups. Results: 40 patients (mean age 40, 92% White, 8% Asian, 15% Hispanic, 15% ≤ high school) completed the survey; 93% had advanced disease and 30% had lung, 25% breast, 10% ovarian, 18% colon, and 17% other cancers. Although 98% had tumor and/or germline profiling on chart review, 33% of patients were unaware this tested occurred. ...