Gene Editing Technologies and Use of Recombinant/Synthetic Nucleic Acids in Laboratory Animals

Gene manipulation technologies are part of the past, present, and future of the domestication of plants and animals. Scientific advances, however, have resulted in those changes being more rapid and precise than ever before. In this review, the authors discuss gene manipulation technologies currently in use, their mechanisms, and their potential biosafety issues, with a focus on mammalian laboratory animals.