Semi-synthesis of Ubiquitin-propargylamide for identifying deubiquitinase targeting inhibitors

Xiaodan Tan,Jingsi Bai,Shan Ding,Yujing Ren, Danning Hong,Ziqing Mei,Yi-Ming Li

Chinese Chemical Letters（2019）

引用 12|浏览6

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摘要

We report a novel semi-synthetic strategy to prepare Ub-PA in large-scale. Biochemical assays prove that semi-synthetic Ub-PA is an effective probe in identifying DUBs targeting inhibitors.

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关键词

Deubiquitinase,Activity-based probe,Ubiquitin-propargylamide,Protein semi-synthesis,Inhibitor identification

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