Quantitative Assessment Of Left Ventricular Function In Myh7 And Mybpc3-Related Hypertrophic Cardiomypathy By Feature-Tracking Magnetic Resonance Imaging

Introduction: Gene mutations in myosin-binding protein C3 (MyBPC3) and beta-myosin heavy chain (MYH7) are the 2 most common genetic cause of hypertrophic cardiomyopathy(HCM). Limited studies compared the systolic function between the patients with the mutations in the 2 genes and the conclusions were indefiniteness. In this study, we compared the ventricular function of HCM patients with these 2 types of genetic mutation with the cardiac magnetic resonance - feature tracking (CMR-FT) derived myocardial deformation Methods: 35 consecutive patients with family HCM (FHCM) underwent genetic testing by next-generation sequencing (NGS) of a broad gene panel. All the patients underwent CMR with 3.0 T scanner. Strain measurements were performed using a dedicated CMR-feature tracking software. Circumferential and radial strain (CS,RS)and strain rate (CSR,RSR) measurements were derived from the basal, mid, and apical sections of short axis cine images. Longitudinal strain (LS) and strain rate (LSR) values were deri...