Abstract 18645: Rare SCN10A Variants Associated With Lone Atrial Fibrillation Modulate Peak and Late Sodium Currents

Eleonora Savio Galimberti,Peter Weeke,Carlos G. Vanoye,Tao Yang, Kaylen C. Kor,Thomas C. Atack,Alfred L. George,Dan M. Roden,Dawood Darbar

Circulation（2013）

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摘要

Introduction: SCN10A encodes the sodium channel isoform Nav1.8, which is variably expressed in atria and has been linked to altered cardiac conduction and atrial fibrillation (AF). We resequenced S...

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