Simultaneous elastic shape optimization for a domain splitting in bone tissue engineering.

This paper deals with the simultaneous optimization of a subset O-0 of some domain Omega and its complement O-1 = Omega\(O-0) over bar both considered as separate elastic objects subject to a set of loading scenarios. If one asks for a configuration which minimizes the maximal elastic cost functional both phases compete for space since elastic shapes usually get mechanically more stable when being enlarged. Such a problem arises in biomechanics where a bioresorbable polymer scaffold is implanted in place of lost bone tissue and in a regeneration phase, new bone tissue grows in the scaffold complement via osteogenesis. In fact, the polymer scaffold should be mechanically stable to bear loading in the early stage regeneration phase and at the same time, the new bone tissue grown in the complement of this scaffold should as well bear the loading. Here, this optimal subdomain splitting problem with appropriate elastic cost functionals is introduced and the existence of optimal two-phase configurations is established for a regularized formulation. Furthermore, based on a phase-field approximation, a finite-element discretization is derived. Numerical experiments are presented for the design of optimal periodic scaffold microstructure.