Unraveling the mechanism and the risk behind seizure liability of lead compounds in a neuroscience project.

Annie Delaunois,Michael V Accardi, Véronique André,Simon Authier,François Bouzom,Simon Hebeisen,Yves Lamberty, Faiza Laredj,Karine Leclercq, Anne-Gaëlle Letombe,Marie-Luce Rosseels,Chiara Carla Rospo, Marie-Christine Tordeur,Jean-Pierre Valentin,Martyn Wood

Journal of Pharmacological and Toxicological Methods（2020）

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摘要

A well-designed set of experiments including electrophysiological assays on seizure-related ion channels and EEG/EMG assessment in telemetered dogs allowed a proper seizure liability risk assessment, leading to a rapid no go decision for the two most advanced leads.

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关键词

Convulsions,EEG,GABAA,Methods,Off-target,Seizure,Telemetry

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