CDC42 regulates the expression of superficial zone molecules in part through the actin cytoskeleton and myocardin-related transcription factor-A: CDC42 REGULATES PRG4 AND TNC EXPRESSION

Justin Parreno
Justin Parreno
Vivian Co
Vivian Co
Po-han Wu
Po-han Wu
Jasmine Chong
Jasmine Chong
Matteo Di Scipio
Matteo Di Scipio

Journal of Orthopaedic Research, pp. 2421-2430, 2018.

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Abstract:

Osteoarthritis (OA) is a degenerative disease that initially manifests as loss of the superficial zone (SZ) of articular cartilage. SZ chondrocytes (SZC) differ in morphology from other chondrocytes as they are elongated and oriented parallel to the tissue surface. Proteoglycan 4 (PRG4) and tenascin C (TNC) are molecules expressed by SZC,...More

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