Maternal metabolic profile predicts high or low risk of an autism pregnancy outcome

•Metabolites from blood samples of pregnant mothers who have a child with autism (High Risk) and pregnant mothers who do not (Low Risk) were analyzed.•High Risk mothers were divided into two subgroups based on the presence (ASD) or absence (TD) of a diagnosis of autism at age 3 of the yet unborn child.•Metabolites did not show significant differences among the two subgroups (ASD vs. TD) of the High Risk group.•Significant differences exist in the metabolites of the High Risk vs. the Low Risk mothers.