A Phase 1 Safety Study Of Sbp-101, A Polyamine Metabolic Inhibitor, For Pancreatic Ductal Adenocarcinoma (Pda).

Niall C. Tebbutt,Dusan Kotasek,Mitesh J. Borad,Erkut Borazanci,S. Smith,Ajit K. Shah,Michael J. Walker,Michael Cullen,Suzanne Gagnon

JOURNAL OF CLINICAL ONCOLOGY（2018）

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摘要

e16231Background: SBP-101 (diethyl dihydroxyhomospermine), a polyamine (PA) analogue of spermine, inhibited growth in 6 human PDA cell lines and 3 murine xenograft tumor models. A Phase 1 dose esca...

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polyamine metabolic inhibitor,pancreatic ductal adenocarcinoma

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