In Vitro Characterization of a Novel Allosteric Potentiator of the Dopamine D1 Receptor

Beverly A. Heinz,John Mehnert Schaus,James P. Beck,Junliang Hao,Xushan Wang,Joseph H. Krushinski,Matthew Robert Reinhard, Sarah Lynne Hellman,Brian G. Getman,Todd M. Suter,David L. Nelson,Todd R. Wiernicki,Michael Philip Cohen,Charles R. Yang,Kjell A. Svensson,Robert F. Bruns

FASEB JOURNAL（2016）

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摘要

Allosteric potentiators of the dopamine D1 receptor could be useful for treatment of Parkinson’s disease, schizophrenia, depression, ADHD, and narcolepsy. We identified a novel D1 potentiator (“DET...

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