Methyl-containing pharmaceuticals: Methylation in drug design

Bioorganic & Medicinal Chemistry Letters（2018）

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摘要

•The methyl groups play important roles in lead optimization.•The methyl groups can modulate many properties of bioactive molecules.•22 beneficial cases are summarized.•Methylation strategy has been successful in drug design.

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关键词

Methyl group,Methylation,Lead optimization,Drug design

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