Abstract 15912: MicroRNA-92a Mediates Endothelial Dysfunction in Chronic Kidney Disease

Introduction: The emerging field in cardiorenal syndrome (CRS) emphasizes the crucial link between chronic kidney disease (CKD) and cardiovascular disease (CVD). Despite the epidemiological evidence supporting the causal relationship between CKD and CVD, the molecular and cellular mechanisms underlying CRS remain unclear. The accumulation of uremic toxins in CKD induces oxidative stress and endothelial dysfunction, further exacerbating kidney damage. Herein, we investigated the role of microRNA-92a (miR-92a), an oxidative-stress responsive miR, in CKD-induced endothelial dysfunction, and its translational relevance. Hypothesis: CKD induces miR-92a in the endothelium, and thereby activate endothelial innate immune response and promote endothelial dysfunction. Methods and Results: In a derivation cohort of CKD patients, circulating levels of miR-92a was significantly increased. This finding was verified in two validation cohorts. Data from 184 patients recruited from 3 sites revealed that circulating miR-92...