5-FU-loaded Nucleoside Nanoparticles for Therapeutic Efficiency of Oral Cancer by various administrations

Drug delivery systems are designed to improve bioavailability, reduce degradation, and alleviate the side effect of the loaded drugs. Here, we reported the development of a novel monomeric self-assembled nucleoside nanoparticle (SNNP) into an efficient drug delivery system in such field. Initially, we used a L-configurational pyrimido[4,5-d]pyrimidine nucleoside building nano-bundles and then found its high biocompatibility and low toxicity in vitro and in vivo. Afterwards, the stability in blood circulation and the distribution of 5-FU in OSCC tissues was remarkably increased by the loading with SNNP. Most importantly, 5-FU-SNNP markedly retarded the in vivo growth of OSCC xenografts in mouse models compared with free 5-FU and SNNP by intratumoral, intraperitoneal and intravenous injection, respectively. It was worth mentioning that, SNNP can even reduce the toxic side effects of 5-FU using intraperitoneal injection on OSCC xenograft mouse model. Furthermore, the superior in vivo antitumor efficacy of 5-FU-SNNP compared with free 5-FU and SNNP was related to inhibit cell proliferation and promote cell apoptosis by TUNEL and immunohistochemistry analyses. These findings indicated that when loaded with 5-FU loaded with SNNP has better antineoplastic efficacy using various administrations and lower side-effects, suggesting that this new type of SNNP has a high hope to be a promising candidate nanoparticle-delivery strategy for cancer therapy clinically in the future. References Hang Zhao, Hui Feng, Dongjuan Liu, Jiang Liu, Ning Ji, Fangman Chen, Xiaobo Luo, Yu Zhou, Hongxia Dan, Xin Zeng, Jing Li, Congkui Sun, Jinyu Meng, Xiaojie Ju, Min Zhou, Hanshuo Yang, Longjiang Li, Xinhua Liang, Liangyin Chu, Lu Jiang, Yang He, and Qianming Chen. Self-Assembling Monomeric Nucleoside Molecular Nanoparticles Loaded with 5-FU Enhancing Therapeutic Efficacy against Oral Cancer. ACS nano. 2015; 9(10): 9638 - 9651. The authors gratefully acknowledge support from the National Natural Science Foundation of China (81520108009, 81500860,81700988). Citation Format: HUI FENG, Hang ZHAO, Ning Ji, Jing Li, Zhiyong Wang, lu jiang, Qianming Chen. 5-FU-loaded Nucleoside Nanoparticles for Therapeutic Efficiency of Oral Cancer by various administrations [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3724.