Mystic Effects of Kisspeptin in Reproduction of Livestock

The commencement of puberty has been interesting topic for reproductive endocrinologists for years. Yet its fundamental physiological mechanisms have stayed mysterious until recently. The findings and understanding of the effects put forth by the peptide hormone kisspeptin have shed light on this research area. Kisspeptin (Kp), a family of neuropeptides which is produced chiefly by neuronal clusters at discrete hypothalamic nuclei, are vital regulators of GnRH neurons. Studies have found a role for Kp to release growth hormone (GH), prolactin and luteinizing hormone (LH) from cattle, rat and monkey pituitary cells. Kisspeptin neuronal system directs both pulsatile GnRH secretion that stimulates folliculogenesis, spermatogenesis and steroidogenesis and the GnRH surge that activates ovulation in females Kisspeptin and related substances could therefore be valuable for the development of novel strategies for the management of fertility in farm animals. To this end, the present review aimed to summarize the current research on kisspeptin and its importance in domestic animals.