Antimycobacterial 1,4-napthoquinone natural products from Moneses uniflora

Haoxin Li,Allyson Bos,Stéphanie Jean,Duncan Webster,Gilles A. Robichaud,John A. Johnson,Christopher A. Gray

Phytochemistry Letters（2018）

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摘要

•The medicinal plant Moneses uniflora contains antimycobacterial naphthoquinones.•5,8-Dihydro-3-hydroxychimaphilin is reported for the first time.•The structure and absolute stereochemistry of glycosylated derivatives is confirmed.•The derivatives display marked selectivity in their bioactivity.•Our data supports a discrete mode of action for naphthoquinones in mycobacteria.

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关键词

Antimycobacterial activity,Medicinal plant,Moneses uniflora,Mycobacterium tuberculosis,Naphthoquinone,Naphthohydroquinone glycoside

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