Acute Toxicity In African American And Caucasian Patients With Adjuvant/Neoadjuvant Chemotherapy For Breast Cancer

1059 Background: The incidence of breast cancer is higher in Caucasian (C) compared to African American (AA) patients (pts), however the mortality is higher in AA. This disparity has been explained by a higher stage at diagnosis, triple negative tumors, high nuclear grade, and decreased access to health care among the AA women pts. This difference still persists when these factors are controlled. We hypothesized that AA pts have reduced dose intensity of chemotherapy due to treatment delays and dose reductions as a result of increased acute toxicity leading to inferior outcomes. Methods: Data was collected by retrospective chart review on 100 consecutive C and 100 AA pts with early stage breast cancer who received adjuvant or neoadjuvant chemotherapy during 2009 to 2011 at a community cancer center. Data collected included pt demographics, comorbidities, disease characteristics, treatment received, acute toxicities, and pt reported symptom burden as assessed by a validated electronic survey. Results: Mean...