Risk of cardiovascular disease associated with exposure to abacavir among individuals with HIV: A systematic review and meta-analyses of results from 17 epidemiologic studies

•Risk of CVD is increased in individuals with HIV recently exposed to abacavir•Risk of CVD is higher among antiretroviral naive individuals receiving abacavir•CVD risk from abacavir use stays elevated after adjusting for CKD or substance use•Further studies are needed to investigate CVD risk from cumulative abacavir use•Biological mechanism underlying observed CVD risk from abacavir use remains unclear