Endogenous n-3 polyunsaturated fatty acids prevent azoxymethane-induced colon tumorigenesis in mice fed a high-fat diet

Schematic diagram showing the mechanism underlying endogenous n-3, PUFA-mediated inhibition of AOM-induced colon tumorigenesis in mice fed a, high-fat diet (HFD). Endogenously synthesised n-3 PUFAs promoted colon tumour cell apoptosis and suppressed proliferation in colon tissue by inhibiting inflammation pathways, including the IL-6/STAT3 and TNF-α/NF-κB pathways and downregulating the activity of the NLRP3 inflammasome, thus, inhibiting colon tumorigenesis in fat-1 mice.