Comparison of LDR Brachytherapy Combined with Conventionally Fractionated EBRT or SBRT in High Risk Node Negative Prostate Cancer Patients: Early Toxicity and Tumor Control Outcomes

One of the most effective radiotherapeutic interventions for the treatment of high-risk prostate is the combination of brachytherapy with supplemental external beam radiotherapy directed to the prostate and regional nodes. While conventionally fractionated external beam radiotherapy has been a standard approach to supplement the brachytherapy boost, we have recently treated such patients with supplemental SBRT using an ultra-hypofractionated regimen. In this study we compare the early toxicity and tumor control outcomes of high risk, node negative patients treated with combination of brachytherapy and SBRT versus brachytherapy and conventionally fractionation RT (CFRT).