EP-1366: Different toxicity rating patients and physicians in randomized phase III PCI vs obs stage III NSCLC

ResultsAnalyses of affected and controls show that homozygote genotype MTHFR 677CC has the highest frequency in both groups in lung and rectal localization, it was 65.38% in patients and 45. 5% in control group in lung localization, 48% in patients with rectal localization and 55% in control group. In breast localization the distribution of the CC, CT and TT genotypes corresponded respectively to the proportions 40%, 55% and 5%. The odds ratio for the TT and CT genotypes was 1.42 (95% CI= 0.42-4.85) and the odds ratio for the TT and CT genotypes was 1.26 (95% CI= 0, 07-21, 49) and 0.69 (95% CI 0.21-2.29. We also demonstrated a modest increase in the risk of breast cancer in individuals with TT genotype compared to the general population (OR= 1.26; 95% CI= 0.07-21.49).