Elevated Levels Of Circulating Neutrophil Extracellular Traps And Prothrombotic State After One Dose Of Chemotherapy To Predict Doxorubicin Cardiotoxicity In Breast Cancer.

e12579Background: Cardiotoxicity of doxorubicin (DOX) is dose-dependent, beginning with the first dose with subclinical myocardial injury that can progress to symptomatic heart failure months or years after infusion. It is important to be able to identify patients at risk during the early doses of chemotherapy. Neutrophil extracellular traps (NETs) contribute to the prothrombotic phenotype in cancer, which is further increased by chemotherapy. Alternatively, elevated levels of circulating exosomes with procoagulant potential were reported in patients with coronary syndromes. This study aimed to determine whether the circulating levels of NETs, exosomes and prothrombotic state can serve as potential biomarkers for presymptomatic DOX-induced cardiotoxicity in breast cancer patients. Methods: Blood samples were collected from breast cancer patients prior to and after the first cycle of DOX-based chemotherapy. Plasma samples of 15 patients who developed an abnormal decline of left ventricle ejection fraction ...