Aminated multiwalled carbon nanotubes/oxidized regenerated cellulose nanocomposites for haemostatic applications

Commercial surgical absorbable hemostatic agents have been widely applied in various surgeries and played an important role on stopping the bleeding. The commercial Oxidized Regenerated Cellulose (ORC) has also shown several inherent disadvantages. To improve the hemostatic effect of ORC, it has been modified by incorporating aminated MWCNTs (MWCNT-NH2). For modification of neat ORC, the MWCNT-NH2s was reacted with neat ORC. The analytical results revealed a relatively strong interaction existed between aminated MWCNTs and the ORC macromolecules. The hydrophilicity test results revealed significant increment in water uptake of MWCNT-NH2s/ORC composites with increasing the concentration of MWCNT-NH2s in composites. The haemostatic evaluation of MWCNT-NH2s/ORC composites on rabbits showed that the aminated MWCNTs increased the rate of blood stopping, decreasing the blood loosing from injured sites.