The Chance Study: A Prospective, Longitudinal Study Of Chemotherapy And Hormonal Therapy Induced Hair Changes And Alopecia, Skin Aging And Nail Changes In Women With Non-Metastatic Breast Cancer.

e12500Background: Late effects such as persistent alopecia, skin aging, and nail dystrophy resulting from cytotoxic or endocrine agents used in early stages of breast cancer are poorly understood. The objective of the study is to describe the incidence, clinical pattern, severity and risk factors for permanent sequelae of adjuvant breast cancer therapies affecting the skin, hair, and nails, and evaluate their impact on patients quality of life (QoL). Methods: This is a single-center, prospective, longitudinal cohort study of non-metastatic breast cancer patients treated with cytotoxic chemotherapies and/or endocrine therapies. A total of 500 patients will be enrolled in each of 5 treatment cohorts, who will be followed for up to 3 years using standardized clinical images, objective skin hydration and elasticity measurements, and patient-reported outcome QoL questionnaires. Results: At data cutoff on 12/2017, 327 patients (65.4% of 500 patients), and 91 volunteers have been enrolled, and the study is ongoi...