Is laser speckle contrast analysis (LASCA) the new kid on the block in systemic sclerosis? A systematic literature review and pilot study to evaluate reliability of LASCA to measure peripheral blood perfusion in scleroderma patients

•A reliable tool to measure the flow is paramount in SSc.•This is the first systematic literature review on the reliability of LASCA in SSc.•The evaluation of peripheral blood perfusion in SSc patients by LASCA is reliable.•LASCA may be a promising tool to be used in therapeutic trials.