Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

Claudia B. Späni,David J. Braun,Linda J. Van Eldik

Frontiers in Neuroendocrinology（2018）

引用 121|浏览12

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摘要

•Sex is an understudied variable in TBI research.•Sex and hormonal status at time of injury influence different outcome measures.•Female mice show a stronger brain inflammation response acutely post-TBI than males.•Female sex hormone treatment can improve certain TBI aspects in preclinical models.•More research into sex differences will enable better treatment strategies for TBI.

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关键词

AAS,APP,BBB,5-CSRTT,CA1,CA3,CBF,CCI,CCL2,CD11b,CHI,CHIMERA,CNS,COX-2,CPP,CXCL1,d,EPM,ER,FPI,GFAP,h,IBA1,ICP,IL-1β,IL-6,IL-10,iNOS,mNSS,mRNA,mTBI,PR,MWM,NIH,SEM,TBI,TGFβ,TNFα,TUNEL,US

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