Structural basis for selective inhibition of antibacterial target MraY, a membrane-bound enzyme involved in peptidoglycan synthesis
Drug Discovery Today(2018)
摘要
•MraY is a promising protein target for antibacterial drugs.•Structures of MraY and of the closely related human GPT have emerged.•Interaction modes of the proteins with natural product inhibitors have been determined.•Structural comparison can aid the design of selective antibacterial MraY inhibitors.
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