Tumor necrosis and clinical outcomes following neoadjuvant therapy in soft tissue sarcoma: A systematic review and meta-analysis

•Poor tumour necrosis following neoadjuvant therapy predicts inferior survival in soft tissue sarcoma.•Isolated limb perfusion was associated with higher odds of achieving ≥90% necrosis.•Tumour necrosis is an important endpoint for studies assessing neoadjuvant therapy in sarcomas.