Tannic acid-derived metal-phenolic networks facilitate PCL nanofiber mesh vascularization by promoting the adhesion and spreading of endothelial cells
JOURNAL OF MATERIALS CHEMISTRY B(2018)
摘要
Synthetic polymer nanofiber meshes produced by electrospinning with a high surface area and suitable porosity mimic the basic structure of the extracellular matrix (ECM) for endothelial cell culture. However, some polymers lacking a cell adhesion surface cause defective vessel formation by cells. Herein, we evaluated metalphenolic networks (MPNs) formed by tannic acid (TA) and metal ions (Fe3+ ions) as nanoscale coating systems on polycaprolactone (PCL) nanofiber surfaces for the modulation of human umbilical vein endothelial cell (HUVEC) morphology and function.
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