Novel Mutations Associated with Clofazimine Resistance in Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy(2018)

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摘要
() is a major non-tuberculous mycobacterial (NTM) pathogen responsible for about 80% of all pulmonary infections caused by rapidly growing mycobacteria. Clofazimine is an effective drug active against and shows synergistic activity when given with amikacin, but the mechanism of resistance to clofazimine in is unknown.
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