S89. EEG reactivity for prognosis in patients after cardiac arrest

Introduction EEG reactivity testing is often suggested to have prognostic value in patients after cardiac arrest. EEG reactivity testing regimens, however, vary and definitions for reactivity are poorly described (Admiraal et al., Eur J Neurol. 2016). We investigate the prognostic value of standardized EEG reactivity testing in a cohort of patients after cardiac arrest. Methods This is a multicenter prospective observational study. We aim to enroll and monitor 160 patients, using continuous (c) EEG, from Results Up till now a total of 141 patients are enrolled; inclusion is expected to be complete in January 2018. In an interim analysis of 80 patients an intra–class correlation coefficient of 0.78 is found for scoring an EEG as ‘reactive’. Of these 80 patients, 39 (49%) have a good outcome. Mean age is 59 (±15) years in the good outcome group and 61 (±14) years in the poor outcome group. Time to return of spontaneous circulation is shorter in the good outcome group, 15 (±12) min versus 25 (±12) min in respectively good and poor outcome groups. Conclusion We conduct a dedicated prospective trial to determine the prognostic value of EEG reactivity and place this modality in the context of other known prognostic markers. An interim analysis showed a good correlation between raters when scoring EEG reactivity and a representative distribution of patient characteristics. Final results on the prognostic value of EEG reactivity will be presented at the conference.