The association of solid-phase assays to immunofluorescence increases the diagnostic accuracy for ANA screening in patients with autoimmune rheumatic diseases

Nicola Bizzaro,Ignazio Brusca,Giulia Previtali,Maria Alessio,Massimo Daves,Stefan Platzgummer,Luigi Cinquanta, Giusy Paura,Maria Infantino,Mariangela Manfredi, Raffaella Faricelli,Danila Bassetti, Maura Musso,Gaia Deleonardi,Maria Teresa Trevisan,Antonella Radice,Marco Liguori,Tiziana Imbastaro,Fiorenza Pesente,Martina Fabris,Elio Tonutti

Autoimmunity Reviews（2018）

引用 46|浏览29

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摘要

•The immunofluorescence (IIF) ANA test lacks specificity and has suboptimal sensitivity for certain antibodies.•Solid-phase assays show higher specificity for ANA screening than IIF.•Currently available solid-phase assays cannot completely substitute the IIF method.•The association of solid-phase assays to IIF increases the diagnostic accuracy for ANA screening.

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关键词

ANA,Antinuclear antibodies,Immunofluorescence,Solid-phase assay,CTD screen

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