Modulation of dendritic cell by pathogen antigens: Where do we stand?

Gabriela Peron, Livia de Lima Thomaz,Larissa Camargo da Rosa,Rodolfo Thomé,Liana Maria Cardoso Verinaud

Immunology Letters（2018）

引用 14|浏览7

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摘要

•DCs have pivotal role in beginning the adaptive immunity.•The success of DC-based vaccination relies on the milieu and antigenic nature.•DCs may acquire an inflammatory or tolerogenic profile when activated.•Tolerogenic dendritic cells (tolDCs) induce differentiation of regulatory T cells.•TolDCs may be used as treatment for inflammatory disorders.

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关键词

DC,tolDCs,PD-1,PD-L1/PD-L2,17XNL,BCG,BMDCs,CCL13,CCR5,CD,DC-SIGN,HCV,CFA,CFU,CTL,DC-SIGN,DNA,EDA,Gag,GM-CSF,HIV,HLA-DR,HSP70,Hsp70- p24 fusion protein,IFN-γ,IgG2a,IL,LCs,LeIF,LPS,MGL,MHC-II,MLN,MR,mRNA,MyD88,NF-kB,NK cell,NS3,OspA,p24 protein,PAMPs,pDCs,PI3K/Akt,Poly IC,RBCs,SCID,SEA,Th1,Th17,Th2,TLR,TNF-α,Treg,WT,EAE,pRBC,SEA,Flt3L,EB,P-Ags

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